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Why don’t animals get heart disease?

According to the World Health Organization (WHO), cardiovascular disease is now the number one killer of humans.
Every year, about 18 million people worldwide die of cardiovascular disease, and by 2030, that number will rise to 23 million.
Cardiovascular disease ruthlessly kills someone in our country every 13 seconds.
The main cause of cardiovascular disease in humans is atherosclerosis. Atherosclerosis plaque deposits on the walls of blood vessels and causes narrowing of the arteries. In the early stage, people will not experience many symptoms until severe coronary artery disease, stroke, renal failure and so on.
But oddly enough, heart disease, which is common in humans, is not a problem that afflicts animals.
In fact, animals almost never get heart disease.
Ah?
You laugh at animals too crazy, animals laugh at you don’t wear.
We thought we were the overlords of the planet, but we turned out to be the poor creatures being played by disease.
The clown was me?
Why do animals avoid heart disease?
This question has baffled countless scientists.
Studies show that the non-mammalian heart is slightly different from ours in that, in addition to its oxygen-supplying blood vessels, it also has sponge-like heart tissue that allows oxygenated blood from the heart chambers to penetrate directly into the heart wall.
In other words, they allow the heart to get oxygen from the blood without the capillaries as a middleman, avoiding the heart attack that can result from a blocked coronary artery.
Reptiles such as Chinese alligators, for example, are protected from heart disease because of their unique heart tissue.
So the hearts of mammals and birds, which are more similar to the human heart, rely on the heart muscle cells, which form tiny capillaries in the coronary arteries, to take in oxygen and expel carbon dioxide.
Wouldn’t their blood vessels become blocked and cause a heart attack?
In principle, so it is, but reality has dealt humanity a heavy blow.
Heart attacks are rare among dogs treated at Oakland Veterinary Hospital in Michigan.
In 2009, two doctors at the University of UCSD published a paper that found that rodents and rabbits were also less likely to develop atherosclerosis.
Are humans really the chosen ones?
Some argue that heart disease is a modern disease brought on by the industrial revolution, and that unhealthy diets rich in red meat and whole dairy products, as well as lack of exercise, are major factors in the treatment of atherosclerosis.
However, 15 percent of cardiovascular disease cases worldwide are not caused by these poor schedules.
To study the causes of heart disease, researchers in the United States conducted an experiment in 2009 in which they transplanted human habits into a group of chimpanzees.
They are sedentary, overeating, and exposed daily to a variety of foods that can lead to high cholesterol and high blood pressure.
Sounds great, doesn’t it? Not too far from high blood pressure?
But there’s nothing wrong with the chimpanzee!
If you do get a heart attack, it’s caused by some kind of inexplicable scarring of the heart muscle that has nothing to do with bad health practices.
In 2019, scientists at the University of California did another experiment in which they genetically modified mice to take out the CmaH gene and compared it with normal mice.
The two groups of mice ate the same food and did not have any different routines, yet the genetically modified mice had at least twice as much fatty deposits in their blood vessels as the normal mice.
Without the CmAh gene, the mice were at significantly increased risk of atherosclerosis, and it is possible that the loss of this gene over the course of evolution is responsible for the susceptibility of humans to cardiovascular disease.
So why does the absence of this gene predispose people to heart disease?
That’s because there’s a substance called Neu5GC in the red meat we eat.
When the substance is snatched up through food, the immune system recognizes it as a foreign molecule and binds to it to produce an antibody, which accumulates in the body, causing chronic inflammation and, eventually, heart disease.
The CMAH gene, on the other hand, produces sialic acid, which helps digest Neu5Gc.
So this is another evolutionary bug?
For now, researchers don’t know why God stole the CMAH gene, but the more reliable theory is that its absence may have given humans the ability to run long distances, a natural selection for the survival of the fittest.
Factory Settings being what they are, it’s hard to avoid them, but there are tried-and-true practices that can help you avoid a heart attack.
In addition to the cliche lifestyle, brushing your teeth well and visiting your doctor regularly can prevent bleeding teeth, inflammation of the gums, and mouth bacteria from entering the bloodstream and forming fatty plaques in the blood vessels.
Also, a strained relationship with your boss may increase your risk of heart disease.
The British Medical Journal published a decade-long study that found that if you don’t deal with your boss every day, you may increase your risk of heart disease by 40%.
Of course, if your heart does fail, there are special treatments for it.
Medical experts have even floated the far-fetched idea of using animal organs to help patients who are waiting for a transplant and can’t find one.
In 2014, scientists announced that a baboon had survived more than a year after a pig’s heart was transplanted into it, taking the idea a step further.
The technique dates back to 1682, when a Dutch surgeon inserted a fragment of a dog’s skull into a Russian soldier’s wound while repairing the skull.
The church was frightened and hurriedly ordered to remove the skull, but the wound had healed and it was too late.
This operation is not artificial leather, it’s not real leather, it’s a real dog.
Even better than dogs are pigs, at least when it comes to heart transplants, which are considered the best choice aside from ethical issues and immune rejection.
A pig’s heart is anatomically similar to a human’s, so it is less likely to spread disease. Genetic tweaks can reduce the ability of immune cells to recognise a pig’s heart as a foreign organ. Adding a gene that produces a human anticoagulant could help prolong the heart’s survival.
Pork’s heart with shrimp may actually be a reality in the future.

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