Chemical name: (8R,9S,10R,13S,14S)-10,13-dimethyl-6-methylidene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
AROMEX 25mg – ALPHA PHARMA
Alpha-Pharma Aromex (aka known as Aromasin, active substance Exemestane, 30 pills x 25 mg) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens classification is the selective estrogen receptor modulators (SERMs), such as Altamofen (Nolvadex) and Promifen (Clomid). AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control.
There exists a gross misunderstanding that has perpetuated the anabolic steroid using and bodybuilding community for years, but the clarification has become much better lately within the last 10 – 15 years. It is the myth and misunderstanding that that SERMs, such as Altamofen (Nolvadex) and Promifen (Clomid), act to lower estrogen levels. This myth most likely stems from the fact that SERMs too are referred to as ‘Estrogen blockers’, and so various individuals may have misunderstood ‘blocking Estrongen’ to mean ‘Estrogen elimination’, which could not be further from the truth. SERMs instead only block the activity of Estrogen in select tissues in the body by way of blocking the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Nolvadex’s case). This is where the “selective” part of ‘selective Estrogen receptor modulator’ comes into play. However, SERMs do no reduce circulating levels of Estrogen in blood plasma. Aromatase inhibitors are the compounds that instead serve to do this by eliminating the production of Estrogen through binding to and disabling the aromatase enzyme, which is the enzyme responsible for the conversion (or aromatization) of androgens into Estrogen.
Aromex is a very strong and very potent steroidal aromatase inhibitor of the suicidal type, and information within the packaging in prescription Aromex describes the ability for Aromex to reduce Estrogen levels by 85%, as evidenced by studies on breast cancer patients. Suicidal aromatase inhibitors such as Aromex (Exemestane) serve to permanently inhibit and disable the aromatase enzyme to which it is bound to. This renders the enzyme inactive forever. The body will eventually manufacture more aromatase enzymes, but the currently bound enzymes are bound indefinitely, eliminating any risk for Estrogen rebound. This is unseen with the other two major aromatase inhibitors (Arimidex and Letrozole), which are non-suicidal aromatase inhibitors that are only bound to the aromatase enzyme for limited time periods before the aromatase inhibitors unbind and become metabolized. If a non-suicidal aromatase inhibitor is halted too abruptly, the circulating inhibited aromatase enzymes that have not been metabolized out of the body will then become free again, and begin aromatizing androgens into Estrogens at an often rapid rate. This is not the case with Aromex.
Aromex is regarded by many anabolic steroid users and bodybuilders as being far more effective and far more useful (due to the suicidal inhibition) than Arimidex, Arimidex still today remains far more popular among the anabolic steroid using community. This is simply because Arimidex was developed and released before Aromex, and therefore anabolic steroid using bodybuilders and athletes took notice of it sooner. Aromex (Exemestane) to a degree was, in a way, overlooked and missed by many. Today this is beginning to change, where many individuals are now noticing the superiority and advantages of Aromex over Arimidex (of which there are many, which will be described in detail throughout this profile). Some of these advantages that are not seen in any other aromatase inhibitors include: suicide inhibition, stimulating increases in IGF-1 (Insulin Like Growth Factor 1), displays little incompatibility with other compounds (something not seen with other aromatase inhibitors), as well as offering less of a negative impact on cholesterol values (again, something unseen with other aromatase inhibitors).
Aromex is a steroidal suicidal aromatase inhibitor. This means that it possesses the characteristic four ring cycloalkane carbon structure common of all steroidal molecules. The fact that Exemestane is a steroidal aromatase inhibitor is the prime reason as to why it is a suicidal aromatase inhibitor that remains permanently bound to the aromatase enzyme. As the aromatase enzyme is highly attracted to the steroidal structure of the androgens (Testosterone) it aromatizes into Estrogen, Aromex’s chemical structure essentially ‘fools’ the aromatase enzyme into binding with it, only to become inhibited/deactivated. Because the binding strength is so great, this inhibition becomes permanent for the aromatase enzyme that Aromex has become bound to. A similar steroidal aromatase inhibitor, Formestane, exhibits the exact same characteristics (although it is much weaker and less potent in comparison to Aromex). This is why there is absolutely no risk of Estrogen rebound when Aromex administration is abruptly halted.
The other two major aromatase inhibitors (Arimidex and Letrozole) are non-steroidal and therefore non-suicidal aromatase inhibitors that are associated with the risks of Estrogen rebound following discontinuation. This is because unlike Aromex, they are not structurally similar to the aromatase enzyme’s target hormones.
Aromex is extremely effective at 25mg daily for the reduction of serum circulating Estrogen levels in the body, as demonstrated earlier with its ability to reduce Estrogen by 85%. As with other second-line breast cancer treatments, Aromex is so effective at inhibiting the aromatase enzyme (and thereby reducing Estrogen levels) that this compound is, like Arimidex, only administered to post-menopausal females, and/or utilized when other first-line treatments for breast cancer has failed. This is because post-menopausal females possess a very different shift in hormone levels and endocrine function in comparison to pre-menopausal females.
Athletes, bodybuilders, and individuals engaging in the use of anabolic steroidswill favor the use of aromatase inhibitors such as Aromex for their usefulness in reducing, mitigating, and avoiding Estrogenic side effects. These side effects are result of the aromatazation (or conversion) of aromatizable androgens (such as Testosterone) into Estrogen, which often results in far greater than normal physiological levels of Estrogen in the body. This is where the use of Aromex (Exemestane) is very beneficial and highly favored among anabolic steroid using individuals, as Aromex eliminates the issue of rising Estrogen levels at the root cause: By binding to and inhibiting/disabling the aromatase enzyme, supraphysiological levels of aromatizable androgens (such as Testosterone, Dianabol, Boldenone, etc.) cannot convert into Estrogen, thereby eliminating any possible risk of Estrogen-related side effects.