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Parkinson’s is linked to osteoarthritis!How to control osteoarthroinflammation and prevent disease?

Osteoarthritis is one of the many forms of arthritis. In fact, inflammation is related to the health of other systems besides the joints.
A recent study published in Arthritis Care & Research found that people with osteoarthritis had an increased risk of developing Parkinson’s disease.

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For the study, the team enrolled 33,360 people aged 50 to 64 years with osteoarthritis (the experimental group) and 33,360 age – and sex-matched people without osteoarthritis (the control group).
The relationship between osteoarthritis and Parkinson’s disease was then calculated and analyzed using various methods.

During a mean follow-up of 7.74 years in the Osteoarthritis group and 8.67 years in the control group, 256 patients developed Parkinson’s disease and 205 patients developed Parkinson’s disease in the Osteoarthritis group.
The researchers found that:

Compared with the control group, patients with osteoarthritis were 41% more likely to develop Parkinson’s disease (adjusted hazard ratio, 1.41;
P = 0.0004).

Patients with arthritis of the knee or hip had a higher risk of Parkinson’s disease than patients without arthritis of the knee or hip or those without osteoarthritis.

Women have a significantly higher risk of Parkinson’s disease than men.

In the patients with osteoarthritis, hypertension, coronary heart disease, diabetes, chronic obstructive pulmonary disease, gout and other complications are also more.
However, while patients with osteoarthritis had a significantly higher risk of Parkinson’s disease, there was no significant difference in all-cause mortality.

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According to the researchers, “We noted increased levels of pro-inflammatory cytokines, such as interleukin-6 and tumor necrosis factor α, in patients with osteoarthritis, which not only decompose cartilage in the bone and joints, but also exacerbate neuroinflammation and activate microglia.”

Of course, a single study is not enough to determine whether there is a relationship between the two diseases, and the study has some potential limitations, such as not taking into account the effects of smoking and drinking on outcomes.
But at the very least, we can make dietary and lifestyle changes that can prevent Osteoarthritis, reduce pain, and improve our quality of life.

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Got osteoarthritis what should notice?

There’s no cure for Osteoarthritis, so pain and symptom management are especially important, and diet may help with symptoms, with The Association of UK Dietitians advising:

One: Maintain a healthy weight

For one thing, being obese or overweight can put pressure on your joints;
On the other hand, excess fat can cause inflammation, which can exacerbate symptoms.
Evidence shows that weight loss can reduce pain and improve physical function and mobility.

For people who are overweight or obese, losing 10 per cent of their body weight will bring good benefits.
Osteoarthritis is associated with type 2 diabetes and cardiovascular disease;
So losing weight can also help prevent or manage these diseases.

BMI is recommended to be controlled within 18.5~24 kg/m;
Keep your waist circumference to no more than 90cm for men and 85cm for women.
Diet can be combined with exercise, as physical activity can help curb neurodegeneration and protect neurons.

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Two: Eat anti-inflammatory fats

The long-chain omega-3 polyunsaturated fatty acids found in oily fish have anti-inflammatory properties and may be beneficial for osteoarthritis.
It is recommended to eat at least two servings a week of oily fish such as sardines, mackerel and salmon.

If deep-sea fish is not available, the British Association of Dietitians recommends considering taking fish oil capsules daily to provide 450mg of EPA+DHA.
Although this is not strictly anti-inflammatory, some studies have shown it can improve pain in people with arthritis of the knee.

Omega-6 polyunsaturated fatty acids and saturated fatty acids have certain pro-inflammatory properties that may worsen symptoms, so it is recommended to reduce consumption of sunflower oil, corn oil, lard and other animal fats.
Eat fats rich in monounsaturated fats, such as canola oil, olive oil, and camellia oil.

Three: Vitamin D supplements

Vitamin D is essential for bone and cartilage health.
Although we can get some vitamin D from our diet, sunlight is the main source of it (subcutaneous 7-dehydrocholesterol is a source of vitamin D3, which is produced in response to UV exposure).
Studies have shown that vitamin D may have positive effects on things like muscle strength, balance and weight management.

We don’t get nearly enough vitamin D on a daily basis, so the British Association of Dietitians recommends daily vitamin D supplements (10-25 micrograms), especially during the winter months.

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Four: Take antioxidant vitamins

Antioxidant vitamins, such as vitamins A, C, and E, may reduce oxidative stress in osteoarthritis.
Although the evidence for the role of these vitamins in osteoarthritis is weak, they can be part of a healthy balanced diet.

Rich sources of vitamin A include: carrots, sweet potatoes, liver, etc. The recommended intake (RNI) is 600-700 micrograms retinol equivalent/day.

Foods rich in vitamin C include citrus fruits, green and red peppers, RNI: 40 mg/day.

Good sources of vitamin E include whole grains, nuts and seeds. The safe amount is 3 to 4 mg per day.

Good sources of vitamin D include oily fish, egg yolks, and certain fortified foods. RNI: 10 micrograms per day.

Good sources of vitamin K include spinach, lettuce, broccoli and Brussels sprouts. Safe intake: 1 microgram per kilogram of body weight per day.

In addition, 30g of nuts and 25g of soy protein, such as tofu, soy milk, soy/edamame, are recommended daily.

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