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Correctly understand growth hormone

Many parents talk about “hormonal” color change, and today we take a closer look at the growth hormone that helps grow taller.

  1. Is growth hormone a hormone? What is the difference from a normal hormone?

A: Many parents talk about “hormonal” discoloration. When they mention hormones, they think of side effects such as body fat, osteoporosis, liver and kidney toxicity. They immediately refused treatment and gave up treatment because they felt that “growth hormone is a hormone and children cannot use”. In fact, there are many types of hormones in the human body, and people commonly refer to “hormones” as glucocorticoids and sex hormones.

Glucocorticoid is a steroid hormone secreted by the adrenal cortex.

Under normal physiological conditions, it has an important regulating effect on the metabolism of nutrients in the body and the functions of various organs, and is one of the hormones necessary to maintain life.

These drugs have strong anti-inflammatory, anti-allergic and immunosuppressive effects. However, when some diseases must be treated with glucocorticoids for a long time, they will slow down growth, and long-term use will have the side effects of centripetal obesity.

Sex hormones are several steroid hormones secreted by the gonadal and adrenal cortex;

The testes mainly secrete testosterone, the ovary mainly secretes estradiol and progesterone, and the adrenal cortex mainly secretes dehydroisoandrosone.

If you take a food or medicine containing sex hormones in a large dose or for a long time, it may cause the early development of reproductive organs and sexual characteristics.

Although growth hormone is also called “hormone”, it is completely different from glucocorticoids and sex hormones in terms of source, chemical structure, physiological and pharmacological effects, and does not produce glucocorticoids or sex hormone-like side effects.

Growth hormone

Growth Hormone (Human Growth Hormone, hGH) is a peptide hormone secreted by the anterior pituitary gland of the human body. Growth hormone stimulates liver and other tissues to produce insulin-like growth factor (IGF-1) to exert its physiological functions, promote bone growth, promote body anabolism and protein synthesis, promote lipolysis, inhibit glucose utilization and increase blood sugar. During puberty, growth hormone, under the synergistic effect of sex hormones, further causes rapid height growth.

  1. Will the growth hormone inhibit the child’s own secretory function?

Answer: It will not affect. The secretion of growth hormone is related to the hypothalamic-pituitary growth axis. Growth hormone replacement therapy does not affect the function of the hypothalamic-pituitary growth axis.

  1. Does growth hormone therapy make children gain weight?

Answer: In general, growth hormone will not cause children to be obese. If a child becomes fat, it may be related to excessive nutrient intake. It is recommended to do more vertical jumping exercises, which is not only beneficial for weight control, but also beneficial for height development.

  1. Does growth hormone cause diabetes?

Answer: Growth hormone does not cause diabetes. Growth hormone can cause a transient increase in blood sugar. Patients with a family history of diabetes need to be highly cautious. Before treatment, blood glucose should be checked for the child. If you use growth hormone, you need to do a regular blood sugar test.

  1. Do girls with short stature use growth hormone therapy, will it cause infertility?

Answer: At present, there is no data showing that it will cause infertility. On the contrary, relevant medical research has confirmed that growth hormone can be used as an adjuvant treatment for certain infertility.

  1. Will growth hormone treatment cause precocious puberty? Make puberty come early?

Answer: Growth hormone treatment does not cause precocious puberty. The mechanism of growth hormone is to promote linear growth of the epiphysis, and only sex hormones promote sexual development. Growth hormone therapy does not advance puberty.

  1. Will growth hormone treatment cause tumors?

A: There has been a lot of medical research abroad, and the medical literature indicates that the incidence of tumors after growth hormone treatment is two to 100,000 to 100,000, which is basically the same as the normal population. There is no obvious difference, indicating that growth hormone treatment will not cause tumors. .

  1. Growth hormone is a “hormone”, will it harm children’s health?

Answer: What we usually call “hormones” generally refers to glucocorticoids, and long-term use will increase the weight of children. However, growth hormone is completely different from glucocorticoid in terms of physiological function, secretion and regulation. For children, the role of growth hormone is to promote the linear growth of bones and make the body grow taller. In addition, it can also promote protein synthesis and accelerate fat breakdown. It is safe to use growth hormone for treatment under the guidance of a doctor.

  1. Is the preservative in growth hormone harmful?

Answer: Growth hormones on the market generally contain phenol as a preservative. Preservatives are not harmful to many growth hormone manufacturers, but many studies have shown that long-term use of phenol preservatives not only corrodes the skin and mucous membranes It has a toxic effect on myocardial liver and kidney, and it has genotoxicity, which can cause chromosome aberration of bone marrow. It is not that there is no harm if the preservatives are controlled within the scope of national standards, it can only be said that the harm is relatively small and relatively safe. What’s more, growth hormone is a long-term medication for children. Adult doses of preservatives are more dangerous in children’s medicines. Therefore, it is safer to choose a growth hormone solution that does not contain preservatives.

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